Immunological Status of Bladder Cancer Patients Based on Urine Leukocyte Composition at Radical Cystectomy.

BACKGROUND: Bladder cancer (BC) is the ninth most common malignancy worldwide, with high rates of recurrence. The use of urine leukocyte composition at the time of radical cystectomy (RC) as a marker for the study of patients' immunological status and to predict the recurrence of muscle-invasive bladder cancer (MIBC) has received little attention. METHODS: Urine and matched peripheral blood samples were collected from 24 MIBC patients at the time of RC. Leukocyte composition and expression of PD-L1 and PD-1 in each subpopulation were determined by flow cytometry. RESULTS: All MIBC patients had leukocytes in urine. There were different proportions of leukocyte subpopulations. The expression of PD-L1 and PD-1 on each subpopulation differed between patients. Neoadjuvant chemotherapy (NAC), smoking status, and the affectation of lymph nodes influenced urine composition. We observed a link between leukocytes in urine and blood circulation. Recurrent patients without NAC and with no affectation of lymph nodes had a higher proportion of lymphocytes, macrophages, and PD-L1+ neutrophils in urine than non-recurrent patients. CONCLUSIONS: Urine leukocyte composition may be a useful tool for analyzing the immunological status of MIBC patients. Urine cellular composition allowed us to identify a new subgroup of LN- patients with a higher risk of recurrence.

Carcinoma urotelial lipoideo de pelvis renal. Aportación de un nuevo caso y revisión de la literatura de esta variante de carcinoma urotelial / Lipid cell variant urothelial carcinoma of the renal pelvis. A case report and literature review

Múltiples son las variantes histológicas del carcinoma urotelial, la mayoría en carcinomas de alto grado, localmente avanzados. Una de las más infrecuentes es la formada por células epiteliales con contenido de lípidos y aspecto de tejido adiposo. De esta variante solo se han publicado 43 casos en vejiga, 2 en pelvis renal y un caso en uréter. Presentamos un tercer caso de pelvis renal. La paciente sigue viva y libre de enfermedad a los 103 meses de la nefroureterectomía. Se revisan los criterios diagnósticos y el impacto pronóstico

There are many variants of urothelial carcinoma. One of the most infrequent is formed by cells with a lipid content and an adipose tissue appearance. Only 43 cases have been reported in the bladder, 2 in the renal pelvis and 1 case in the ureter. We present a third case in the renal pelvis; the patient is alive and free of disease 103 months post diagnosis

[Lipid cell variant urothelial carcinoma of the renal pelvis. A case report and literature review]. / Carcinoma urotelial lipoideo de pelvis renal. Aportación de un nuevo caso y revisión de la literatura de esta variante de carcinoma urotelial.

There are many variants of urothelial carcinoma. One of the most infrequent is formed by cells with a lipid content and an adipose tissue appearance. Only 43 cases have been reported in the bladder, 2 in the renal pelvis and 1 case in the ureter. We present a third case in the renal pelvis; the patient is alive and free of disease 103 months post diagnosis.